My son, our home-grown IT dept, set me up with Crash Plan to back up to a separate EHD. I have 2 EHDs, one for files and design stuff, and one for the back-up. I should have an off-site BU, too.
If I'd had two forms of backup when my HD crash occurred, I could have backed everything right back on to my new hard drive from an EHD, skipping the whole business with Mozy.
So, I guess the moral of the story is to have two forms of back-up, on- and off- site. That's so you're covered in most eventualities. Off-site in case your home is burgled, a house fire, etc; on-site in case of a hardware failure.
Crash Plan does have an off-site option; just make sure it can back up your EHDs, too. Back Blaze is another option.
I have a Pro account with Flickr, for unlimited uploads. It's $25 a year.