The way PSE 6 is designed it uses a lot more RAM than previous versions. You may want to not only defrag often (and save often LOL) but check your Edit/Preferences/Performance. You'll want to see what kind of Available RAM you have along with how much you are allowing PSE to use. Then down below there is your scratch disk options. If you have a partitioned hard drive or even an external that is ALWAYS hooked up, you could set those a secondary scratch disk to your main C: drive.
Deb, if text is what's killing your PSE you may have too many fonts. Windows and fonts are not great at working together. I uninstalled 165 and my computer ran considerably better. In photoshop you have this cool thing where you can have a font that is NOT installed on your windows system show up in the list for just that one time. BEFORE opening PSE, open the font preview (The lazy brown fox... page that shows you what the font will look like), then keep it open while you open PSE. It will then show up on your list just until you are finished with that layout. I have a soccer font that is adorable but I only use 1 time a year so I created an index sheet with cute, but not needed fonts, uninstalled them and put them in a folder on my EHD and only use them when needed. Hope that helps!